RESEARCH STUDIES
The Science behind BLIS K12™
BLIS K12™ is naturally occurring, strain of the common oral bacteria called S. salivarius. BLIS Technologies Ltd has patented this unique strain and called it BLIS K12™.
| Link To | Keywords |
| PubMed.gov | Streptococcus Salivarius k12 |
BLIS K12 reference list of peer reviewed studies and book chapters:
| Researcher | Year | Country of Research | Study Title & Publication |
ORAL INFECTIONS |
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| Tagg et al | 2008 | New Zealand |
Streptococci as effector organisms for probiotic and replacement therapy. Therapeutic Microbiology: Probiotics and Other Therapies. Edited by Versalovic J & Wilson M. (American Society for Microbiology Press) Streptococci as effector organisms for probiotic and replacement therapy. Therapeutic Microbiology: Probiotics and Other Therapies. Edited by Versalovic J & Wilson M. (American Society for Microbiology Press) Streptococci as effector organisms for probiotic and replacement therapy. Therapeutic Microbiology: Probiotics and Other Therapies. Edited by Versalovic J & Wilson M. (American Society for Microbiology Press) |
| Horz et al. | 2007 | Germany | Distribution and persistence of probiotic Streptococcus salivarius K12 in the human oral cavity as determined by real-time quantitative polymerase chain reaction. Oral Microbiol Immunol. 2007 Apr;22 (2):126-30. |
| Tagg et al. | 2006 | New Zealand | Oral streptococcal BLIS: Heterogeneity of the effector molecules and potential role in the prevention of streptococcal infections, International Congress Series, 2006, Vol 128: 347-350 |
| Tagg et al. | 2004 |
New Zealand |
Prevention of streptococcal pharyngitis by anti-Streptococcus pyogenes bacteriocin-like inhibitory substances (BLIS) produced by Streptococcus salivarius. Indian J Med Res. 2004 May;119 Suppl:13-6. |
| Tagg et al. | 2003 | New Zealand |
Bacterial replacement therapy: adapting 'germ warfare' to infection prevention. Trends in Biotechnology. 21(5): 217-23. |
PERIODONTAL DISEASE |
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| James & Tagg |
1991 | New Zealand |
The prevention of dental caries by BLIS-mediated inhibition of mutans streptococci. N Z Dent J. 1991 Jul;87(389):80-3. |
UPPER RESPIRATORY TRACT INFECTIONS |
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| Power et al. |
2008 | New Zealand |
Preliminary investigations of the colonisation of upper respiratory tract tissues of infants using a paediatric formulation of the oral probiotic Streptococcus salivarius K12. Eur J Clin Microbiol Infect Dis. 2008 Jun 17. |
HALITOSIS |
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| Burton et al. |
2005 | New Zealand |
The rationale and potential for the reduction of oral malodour using Streptococcus salivarius probiotics, Oral Diseases (2005) 11 (Suppl. 1), 29–31 |
| Burton et al. |
2006 |
New Zealand |
A preliminary study of the effect of probiotic Streptococcus salivarius K12 on oral malodour parameters, J Appl Microbiol. 2006 Apr; 100(4):754-64. |
SAFETY |
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| Burton et al. | 2006 |
New Zealand |
Safety assessment of the oral cavity probiotic Streptococcus salivarius K12. Appl Environ Microbiol. 2006 Apr;72(4):3050-3. |
IMMUNITY |
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| Cosseau et al. |
2008 | Canada and United Kingdom |
The commensal Streptococcus salivarius K12 down-regulates the innate immune responses of human epithelial cells and promotes hostmicrobe homeostasis. Infection and Immunity, Sept. 2008, p. 4163–4175 |
OTITIS MEDIA
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| Tagg et al. |
2003 |
New Zealand |
Bacteriocin-like inhibitory substance (BLIS) production by the normal flora of the nasopharynx: potential to protect against otitis media? J Med Microbiol. 2003 Sep;52(Pt 9):829-33. |
| Wescombe et al. |
2006 | New Zealand & Canada |
Megaplasmids encode differing combinations of lantibiotics in Streptococcus salivarius, Antonie Van Leeuwenhoek. 2006 Oct;90 (3):269-80 |
| Tagg et al. |
2003 |
New Zealand |
Bacterial replacement therapy: adapting ‘germ warfare’ to infection prevention, Trends Biotechnol. 2003 May;21 (5):217-23. |
| Heng et al. | 2006 |
New Zealand |
The Diversity of bacteriocins produced by Grampositive bacteria. (Book Chapter) Evolution and Ecology of Bacteriocins. Springer New York, Editor: M Riley. |
| Hyink et al. |
2007 |
New Zealand |
Salivaricin A2 and the novel antibiotic salivaricin B, are encoded by adjacent loci on a 190 kb transmissible megaplasmid in the oral probiotic strain Streptococcus salivarius K12. Appl Environ Microbiol 73(4): 1107-13. |
| Wescombe et al. |
2006 |
New Zealand |
Production of the lantibiotic salivaricin A and its variants by oral streptococci and use of a specific induction assay to detect their presence in human saliva. Appl Environ Microbiol. 2006 Feb;72(2):1459-66. |